Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. I have others mentioned in this post: (This page contains a link to products for purchase. 6. Not landscapers just the people that own their homes. Research is already being hurriedly done in that direction in the hope that many lives can be saved and much severe illness avoided. Several P2Y12 inhibitors are approved to treat heart disease, but other purinergic receptors are likely to be more important in ASD. Nos gustara mantener en contacto! Also, Suramin not only blocks P2X7 but also the related Pannexin 1 channel. Accelerated catch-up development occurs in the first few weeks when the brakes are removed because the child is ready to develop, but was otherwise blocked by their illness. According to a comment on a doctor video "Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. "Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin." How much would one have to drink to get the effects of reversing Autism? The first shoots used to be used as a spring tonic many years ago. Once all the needles have sunk to the bottom and the tea has . But for now, I have taken the route of buying Dandelion Tea from the Health Shop. The purpose of this website is to promote broad consumer understanding and knowledge of various health topics. This is a deplorable fact, and a very scary one. About 500-1000 mg of fish oil per day is recommended for children dealing with ADHD. So because of all this people take their safe and effective jab believing that no-one would do anything to harm them not unless they are a murderer, or maybe a terrorists! If interested look up her name and look for turpentine video. 9. [2], The most frequent adverse reactions are nausea, vomiting, diarrhea, abdominal pain, and a feeling of general discomfort. You quoted Rheum Palmatum, but many other plants contain Emodin. ! "In the '100 Years of Suramin' Study (the following paragraph within the subtitle "(Too) Many Targets") outlines its antidote properties to the spike protein contagion (derived from the mRNA that gives instructions to replicate a spike protein in other . Ive used it many times, but it is so true. Eastern White Pine Tree Needles: A Natural Source of Anti-Infective Compounds, Suramin is strongly inhibitory to the replication of the coronavirus spike protein. i'm not sure why i'm saying that med, but for some reason it came up in my research around suramin alternatives. Virol J 13, 149 (2016). It loves the cold, the colder the better. 3 (1985): 265-273. It has a sweet taste and I like it. (especially on purinergic signaling.) doi: https://doi.org/10.1101/2020.10.06.328336. Turn your volume down inititially. Suramin (suramin hexasodium; CI-1003) is a polysulfonated naphthylurea. https://www.biorxiv.org/content/10.1101/2020.10.06.328336v1, 3. COVID-19 pandemic. They were ahead of their time back then. One of them cannot be true. Jacques Update:Facebook and social media platforms are cracking down on Conservative/holistic health content. Further development of suramin was passed from Dr. Naviauxs university research lab to the private sector. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. New antipurinergic drugs (antagonists) and propurinergic drugs (agonists) are now being synthesized and tested but few have yet completed Phase 3 clinical trials and been approved. (See protocol below). ", 13. (2020). They are SO strict with raw over here. [10] Suramin can also cause loss of appetite and irritability. Descriptions. UC San Diego Health, May 26, 2017, "Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy", "Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial", "Q and A - Suramin and Autism | UC San Diego Health", "Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases", https://en.wikipedia.org/w/index.php?title=Suramin&oldid=1126333005, Antrypol, 309 Fourneau, Bayer 205, others, This page was last edited on 8 December 2022, at 20:02. This has the effect of blocking downstream G protein mediated signaling of various GPCR proteins including rhodopsin, the A1 adenosine receptor, the D2 receptor,[19] the P2 receptor,[20][21] and ryanodine receptors. [3] It is given by injection into a vein. He also talks about some other VERY interesting information that you have to hear for yourself And of course, a health disclaimer. Suramin is not extensively metabolized and about 80% is eliminated via the kidneys. The synthesis of suramin was an extension of Paul Ehrlichs pioneering work that showed that certain chemical dyes were concentrated in microbial parasites like the trypanosomes that cause African sleeping sickness. You can inoculate the tiniest amount of Suramin and reverse Autism! Having its feet covered in snow suits it just fine. Happy researching. 20. A small, FDA-approved phase 1 clinical trial in 2017 tested suramin's effect on certain "core" autism symptoms in five boys, as compared with five boys given a placebo. Natural Protocol: This protocol may mitigate damage in those with "buyer's remorse" who've been injected with spike protein, graphene oxide, SM-102, and mRNA.The same protocol is very useful to protect those concerned with the spike protein transmission FROM those who've been injected.. Weekly updates on the topics that matter the most to you! Funny how uridine is a p2y2 agonist and so many people take it as a nootropic. Do you have any sense of whether the pine needles are higher than the others in suramin? '+arguments[1].video:'')+"/?url="+encodeURIComponent(location.href)+"&args="+encodeURIComponent(JSON.stringify([].slice.apply(arguments))),e.parentNode.insertBefore(l,e)}})}(window, document, "script", "Rumble"); Rumble("play", {"video":"vh8kgv","div":"rumble_vh8kgv"}); Let food be thy medicine and medicine be thy food. ~Hippocrates, So do not fear, for I am with you; do not be dismayed, for I am your God. "Understanding the mechanism of the antimitogenic activity of suramin. "Antiproliferative effects of suramin on lymphoid cells." You must log in or register to reply here. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 M), and SirT5 (IC50=22 M). I'm not too concerned about Il-6 being a problem in CFS but I've thought about that receptor a bit. The mark of the evil one is this: when people sell their souls to the devil by participating in ghastly human and ch/ild sa/crifice so they can obtain more power, finances and fame. Oh my, you made me remember my brother and I when we were young. "Suramin: an anticancer drug with a unique mechanism of action. are there any meds that might be good alternatives to suramin? The richest sources of life-giving suramin today are conifers growing in ecologically clean regions of Siberia. Green tea research shows an amelioration of behavioral aberrations by a daily intake dose of the extract; doses range from 75 to 300 mg/kg after postnatal day 14 up to day 40 in animals with . It is our hope that each success will lay the groundwork for more successes, and soon there will be a drug, device, and therapeutic Renaissance that will create dozens of new tools that doctors can use to regulate the cell danger response and help patients heal. Structural Basis For Repurposing A 100-Years-Old Drug Suramin For Treating COVID-19. Thanks for being part of this journey with me. 6 (1992): 2166-2174. Suramin as medication is used to treat African sleeping sickness and river blindness. The more stress, the more eATP is released. You can obtain enough from pine needle tea (pine, spruce, cedar and fir) . Journal of clinical oncology 10, no. [9], It has been used in the treatment of river blindness (onchocerciasis). to protect from transmission from the V and to help those who took the V, We are covering everything from vaccines, parenting topics, alternative medicine, and. No Carter, not really. (2020). Boom-chakalaka, phreaks! Researchers Studying Century-Old Drug in Potential New Approach to Autism. I dont know but I do know that God will provide. I have been taking Sytrinol, 150 mg x 2 daily, for well over 6 months. XXIV. Research is already being hurriedly done in that direction in the hope that many lives can be saved and much severe illness avoided. "Suramin inhibition of growth factor receptor binding and mitogenicity in AKR2B cells. This is the most important Antidote. antiviral activities [24], and most of these are generally of low toxicity, cheap and 2! More Powerful Immune System Boosters By Using Essential Oils! Jason Shurka was interviewing Dr Judy Mikovits PhD., and he asked the leading question: Do you know of any way, to heal oneself from the injuries from the current injection? It is illegal to use suramin in humans for any purpose in the US except in FDA-approved clinical trials. And this video discusses the findings of graphene oxide and how it sets into motion a whole cascade of inflammatory responses and cell death in you or a loved one. y puede cancelar su suscripcin en cualquier momento. The N/W/O and all their minions. Current status of the nomenclature and properties of P2X receptors and their subunits", "Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676", "Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480", Scott LaFee and Heather Buschman. There was some discussion on Phoenix rising about alternatives but it all got a bit confusing for me. Here he talks about suramin, which Dr Judy mentioned. Ph-D Boric Vaginal Suppositories 36 Count Each Exp 10/23. Any natural medicine with 0.01% of these deaths and side effects would have been pulled from the market immediately. 15.Mooon, Jeong-jo, Young-bok Han, and Jin-suk Kim. Yin, W. et al. Reddit and its partners use cookies and similar technologies to provide you with a better experience. The boys were extensively monitored in the following 6 weeks for suramin blood levels, a panel of blood chemistry, adverse effects and autism-related traits. Thank you!). When he had an ME attack (as he called them), he would boil a load of soya beans, which he claimed made him feel much better. But people of today seem to think they can consume anything they like and they dont expect that it will make them sick! recommended to aid the liver detoxify Tylenol overdoses, FDA recently made it illegal to purchase OTC, prevent blood clots by safely dissolving fibrin, breaks down proteins into smaller particles and is antiinflammatory, chalcone like quercetin that deactivates spike protein, Nebulizing NanoSilver or Glutathione for Lungs & More: The How To, Prepare NOW While Prices Are Still Lower. 5. Im worried about the mark of the evil one. National Institutes of Health. [2], It is unknown whether it is safe for the baby when a woman takes it while breastfeeding. Pine Trees are widely available throughout the world and make an amazing tea high in vitamin C and A. So if they sell their homewho knows. i just emailed a well known ME/CFS doctor i know (who wishes to remain anonymous) with the names of the two herbs/supplements mentioned at the top of this thread, and he said: "I have talked with every prominent herbalist I know to see if there is a similar substance out there, and so far, nothing.". A polyanionic compound with an unknown mechanism of action. $8.99 to $12.75. I think thats an old wives tale. 2 (1991): 155-157. National Center for Biotechnology Information. An in silico drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both representing attractive therapeutic targets for many chronic inflammatory conditions. It is a growth factor antagonist for palliative treatment in hormone-refractory prostate cancer and hormone-responsive metastatic prostate cancer.. Purpose. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 M). She was annoyed people were being told to make it. Acta Biomater 84, 378-390. The Neem's active substance, azadirachtin, 51 a tetranortriterpenoid plant limonoid, is a potent insect feeding deterrent and, if consumed, 52 causes . [10] Other skin reactions include skin rash, swelling and stinging sensation. And yes my neighbors thought I was crazy when they saw me collecting them. LifeWave X39 and X49 Performance Bundle - 30 Patch. "Antiproliferative effects of suramin on lymphoid cells. et Zucc. "Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer." Roundup is not sprayed on lawns. northwestern Africa and North America, is known . My high quality source was, of course, wikipedia, but here are some better ones. Alcohol, well Ethanol, is not a p2x antagonist. As we know, oil and water do not mix, but this mixes the oil into the water long enough for me to have a drink. Medical Disclaimer: I am no longer a practicing medical professional, and I am not doctor. POLG Mutations Associated with Alpers Syndrome and Mitochondrial DNA Depletion. Suramin works by causing the parasites to lose energy, which causes their death. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. I find one of the best ways to consume a tea that you are not so fond of is to mix it up with one or more other teas. It is the treatment of choice for sleeping sickness without central nervous system involvement. One day I just may try that. They do change our DNA in the sense that they take it back to how it was when we were a baby. . [2], Suramin was made at least as early as 1916. Unfortunately, the importance of ATP and related metabolites in regulating the symptoms of disease and the stages of the healing cycle has only recently been recognized. [5] It is on the World Health Organization's List of Essential Medicines. [23], Suramin has been studied in a mouse model of autism and in a small phase I/II human trial. I am not a total fan of the taste but absolutely love the aroma of it before the water hits it. That our professionals and decision-makers have continued to allow this sham to . Maca Root 8050mg Per Caps, 4 Months' Supply Supports Reproductive Health Natural. I always come back to the analogy of a car. Press J to jump to the feed. Weve tried everything else. This recent study was double-blind, placebo-controlled and involved 10 boys, ages 5 to 14 years, [] Try to put aside your previous teaching and open your spirit to receive from God. No medical research confirms this yet, but people have been using suramin for autism and as a powerful antiviral. Some of the other P2X7 and P2Y2 inhibiting compounds listed at the bottom of. Suramin is not approved for any use in humans in the United States except to handle the few cases of African sleeping sickness (trypanosomiasis) that have recently traveled from Africa. [10] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision. Based on this system, we have demonstrated that an aqueous extract from the Natural herb Prunella vulgaris (NhPV) displayed potent inhibitory effects on SCoV-2 SP (including SPG614 mutant) pseudotyped virus (SCoV-2-SP-PVs) mediated infections. A few Dandelion leaves in salads are good, and Fennel is great to eat. This tea helps with vascular and heart diseases. Curcumin was the active ingredient in an intravenous infusion that killed the patient of a California-licensed naturopathic doctor. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. Any natural medicine with 0.01% of these deaths and side effects would have been pulled from the market immediately . so i do wonder what the one is behind Suramin. It is still early to say but maybe this will enter the top three interventions. A small, but promising clinical trial in the US has shown that a 100-year-old drug called suramin can measurably improve the symptoms of autism spectrum disorder ( ASD) in children. 1! Cat's Claw. If you continue to use this site we will assume that you are happy with it. [11] Once inside parasites, suramin combines with proteins, especially trypanosomal glycolytic enzymes, to inhibit energy metabolism. Though it has been investigated for other diseases, including cancer, it is not approved for any therapeutic use in the United States. Still, I do drink it occasionally. I will strengthen you and help you; I will uphold you with my righteous right hand.~Isaiah 41:10, Deep Roots At Home now has a PODCAST! [15], The mechanism of action for suramin is unclear, but it is thought that parasites are able to selectively uptake suramin via receptor-mediated endocytosis of drug that is bound to low-density lipoproteins and, to a lesser extent, other serum proteins. All rights reserved / Site by, Post-treatment Lyme disease syndrome (PTLDS), Post-coccidiomycosis (Valley fever) chronic fatigue syndrome, Treatment-Resistant Major Depressive Disorder with suicidal ideation, NARP, Leigh, and other Primary Mitochondrial Diseases, Post-chemotherapy cognitive impairment, fragility, and accelerated aging symptoms, Chronic pain syndromes in children and adults, Drug addiction recovery therapy, e.g., opioid addiction with hyperkatifeia, Treatment-resistant, post-COVID long-haulers with multisystem chronic fatigue syndrome, Severe Obsessive-Compulsive Disorder (OCD), Pediatric acute-onset neuropsychiatric syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), As an additive in organ transplant media to improve organ survival, and decrease inflammation and rejection, Subacute-chronic traumatic brain injury (TBI), Postural orthostatic tachycardia syndrome (POTS)/Dysautonomia. He knew they would tamper with our food supply, robbing it of all the necessary nutrients for life and health. All parts of the dandelion are edible. Create an account to follow your favorite communities and start taking part in conversations. 4 (1993): 701-710. interesting! Using remedies is a personal decision. It has been recognized by prominent researchers for its abilities to lower cholesterol, protect against heart disease and even act as a preventive measure to avoid heart disease. The natural alternative of Suramin - and the original compound is found in Eastern White Pine (pinus strobus) needles. We strongly caution against the unauthorized use of suramin.1Homeopathic use of suramin is also illegal and untested. The first thing we noticed was the improvement in his articulation. Thats because I buy Fennel essential oil (100% pure, therapeutic grade) and drop a couple of drops into my bottle of water. Antiviral research 7, no. This has me very excited. [11], The synthesis of suramin itself and structural analogs is by successive formation of the amide bonds from their corresponding amine (aniline) and carboxyl (as acyl chloride) components. Now, a new study reviews the potential for curcumin, a natural alkaloid derived from turmeric, and nanosystems to treat COVID-19. Outside of that, they believe the governments, the medical profession and even their church leaders would never do anything to harm them. Check with your physician if you . There is a lot of research available on the internet about this. Coffey Jr, Robert J., Edward B. Leof, Gary D. Shipley, and Harold L. Moses. Did it excellently as well. Further investigation of the herb reveals a study (Smith . Journal of Biological Chemistry 295, no. In conjunction with P2X7 that's the main pathway for leaked eATP. and this shows what Graphene oxide does to the blood of the vaccinated under the microscope: This protocol may mitigate damage in those with buyers remorse whove been injected with spike protein, graphene oxide, SM-102, and mRNA. Antiviral Res 143, 230-236. For a better experience, please enable JavaScript in your browser before proceeding. It likes to be on the cold side of the mountain and doesnt do well on the warmer side. Content may not be reproduced in any form. [24][25][26][27], 8,8'-{Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}di(1,3,5-naphthalenetrisulfonic acid), O=C(Nc1cc(ccc1C)C(=O)Nc3c2c(cc(cc2c(cc3)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c8cccc(NC(=O)Nc7cc(C(=O)Nc6cc(C(=O)Nc5c4c(cc(cc4c(cc5)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)ccc6C)ccc7)c8, InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80), The references used may be made clearer with a different or consistent style of, World Health Organization's List of Essential Medicines, Learn how and when to remove this template message, "Suramin Injection Advanced Patient Information", "Micromedex Detailed Drug Information for the Consumer: Suramin (Injection route)", "Our Formulary Infectious Diseases Laboratories CDC", "Trypanosomiasis, human African (sleeping sickness)", "CDC Infectious Diseases Laboratory: Our Formulary", "Suramin Injection Advanced Patient Information - Drugs.com", "Synthesis and StructureActivity Relationships of Suramin-Derived P2Y, "Inhibition of receptor/G protein coupling by suramin analogues", "International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy", "International union of pharmacology. Because He knew that we would move far away from the foods He designed for us. I love the way she says that they wouldnt be injecting people unless they already knew what could be done to reverse it. A: Generally acceptable. Stay Healthy from the Field of Master Mind Herbs (MMHRB). I will continue to research it, but at this time Im not convinced. The intracellular application of 100 mM ethanol did not affect the inhibition of current by 100 mM extracellular ethanol, suggesting that the alcohol inhibition of ATP-gated ion channel function involves the extracellular domain of the receptor. [11], Less common side effects include extreme fatigue, ulcers in the mouth, and painful tender glands in the neck, armpits and groin. Common side effects of suramin include shock, dizziness, fatigue, headache, loss of consciousness, peripheral nerve damage (neuropathy . The respective distribution of glycosome volumes and for cells treated for 72 h with suramin is shown as a bar graph. JavaScript is disabled. Various routes to these compounds have been developed, including starting from separate naphthalene structures and building towards an eventual unification by formation of the urea[13][14] or starting with a urea and appending successive groups. [6] In the United States it can be acquired from the Centers for Disease Control (CDC). I'm fascinated and excited by this new research on cell danger response (CDR): Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial abstract and the ramifications for autism as well as anxiety and other chronic health conditions. Suramin is used in the treatment of African sleeping sickness (African trypanosomiasis) and river blindness (onchocerciasis), infections caused by parasites. But this so-called pest, this common pine tree, is packed full of goodness! Suramin has no listed mild interactions with other drugs. especially valuable as potential new sources for rapid responses against the ongoing 4! [2] Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur. I tried it for the lipid modulating properties and have seen some improvement in various serum lipid ratios (though of course I don't know that this is specifically attributable to the Sytrinol). Not all are safe to make tea out of. Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles. or Best Offer. I dont ever recommend any products that I do not believe is 100% beneficial to my clients. Suramin Definition. [12], Suramin is not orally bioavailable and must be given intravenously. 4. It is a symmetric molecule in the center of which lies a urea (NHCONH) functional group. It is more like removing the brakes then pressing the accelerator. Thank you, Jo . Biochemistry 45, no. Usted recibir 1 2 correos electrnicos al mes (incluyendo los regalos de temporada!) The same protocol is very useful to protect those concerned with the spike protein transmission FROM those whove been injected. To evaluate the localization of this presumed alcohol binding site, the effect of the intracellular application of ethanol was studied on the inhibition of ATP-activated current by extracellularly applied ethanol. "Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Dr. Naviaux frequently says, Our work is not about suramin, or any other single drug. Are you aware of anything?. If this works, it would literally be an answered prayer ! & Naviaux, R.K. Optical phenotyping of human mitochondria in a biocavity laser. B-complex vitamins: The "complex" part is important. For more information, please see our FAQ. As her life is hounded by the authorities, Im guessing maybe she has had to back-peddle for the sake of her life. [2] Severe side effects may include low blood pressure, decreased level of consciousness, kidney problems, and low blood cell levels.