To avoid this interaction, take strontium at least 2 hours before or after taking quinolones. N Engl J Med 2004;350:459-68.. View abstract. View abstract. (Accessed 8 August 2006). Reginster, J. Y., Lecart, M. P., Deroisy, R., and Lousberg, C. Strontium ranelate: a new paradigm in the treatment of osteoporosis. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Malaise, O., Bruyere, O., and Reginster, J. Y. Strontium ranelate normalizes bone mineral density in osteopenic patients. Pennington JA, Jones JW. 2006;3:CD005326. The next big and interesting use of this alkaline earth metal was when it was used in the television production industry, specifically in the cathode ray tubes of color televisions. 11 possible benefits. I. Inhibition of intestinal calcium absorption and 1,25-dihydroxycholecalciferol synthesis. Zhai, H., Hannon, W., Hahn, G. S., Harper, R. A., Pelosi, A., and Maibach, H. I. Strontium nitrate decreased histamine-induced itch magnitude and duration in man. View abstract. are clickable links to medically peer-reviewed studies. N.Engl.J.Med. It is said to have first been found in the ores of lead mines in Strontian in 1787. 2004;19(8):1241-1249. Strontium is a mineral and alkaline earth metal like calcium, and it seems to work similarly to calcium in the body with its main benefit being a boost to bone health. https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869. I am fortunate to have no noticeable side effects. Cochrane Database Syst Rev 2005;(2):CD002946. View abstract. View abstract. View abstract. Pearce, E. I. and Sissons, C. H. The concomitant deposition of strontium and fluoride in dental plaque. @kishanvasekar My girlfriend has osteoporosis and the Dr put her on high doses of Vit D-3 sunshine exercise especially weights ,swimming .She is doing good. Calcium citrate has an acidic base, so it doesn't require hydrochloric acid for absorption. 1972;43(6):367-372. View abstract. Arrich, J., Piribauer, F., Mad, P., Schmid, D., Klaushofer, K., and Mullner, M. Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis. View abstract. Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies. Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. Strontium(89) chloride versus palliative local field radiotherapy in patients with hormonal escaped prostate cancer: a phase III study of the European Organisation for Research and Treatment of Cancer, Genitourinary Group. Expert.Opin.Investig.Drugs 2004;13(7):857-864. Reginster, J. Y., Felsenberg, D., Boonen, S., Diez-Perez, A., Rizzoli, R., Brandi, M. L., Spector, T. D., Brixen, K., Goemaere, S., Cormier, C., Balogh, A., Delmas, P. D., and Meunier, P. J. Osteoporos.Int. A., Mohr, D. N., Petterson, T. M., O'Fallon, W. M., and Melton, L. J., III. 2005;16(10):1291-1298. In 2013, the committee of the European Medicines Agency (similar to the FDA in the United States) recommended suspending strontium ranelate (brand name Protelos/Osseor) for treating osteoporosis. [3] Bartl, R. & Bartl, C.The Osteoporosis Manual: Prevention. View abstract. Previous research demonstrates that strontium ranelate can promote bone formation while decreasing vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis. Kanapka, J. The application of Sr-89 is cost-effective, especially when compared with [opioid painkillers]. Cummings SR, McClung MR Christiansen C et al. J Periodontol. Oosterhof GO, Roberts JT, de Reijke TM, et al. Health Phys 2004;86:193-6. J.Periodontol. View abstract. Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. The objective of this study was to determine whether strontium citrate can be used to enhance bone healing during MDO in a rabbit model. 1970;41(12):702-703. (14). J Clin.Dent. All rights reserved. View abstract. This decreases the amount of tetracyclines that can be absorbed. Keep in mind that more research is still needed to confirm its benefits and safety for some of these uses. If youre not into chemistry, then those scientific facts probably dont mean that much to you. View abstract. Unfortunately, a lot of toothpastes that contain Sr may contain a lot of other questionable ingredients, so I recommend sticking with a natural toothpaste or making your own at home such as myHomemade Probiotic Toothpaste. Protelos European Summary of Product Characteristics. View abstract. The forms of strontium available over-the-counter in the U.S. or on the Internet are usually strontium citrate or strontium chloride. 2008;39(4):321-325. J Periodontol 1987;58:470-4. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. J.Thromb.Haemost. J Bone Miner Res 2001;16:299-308. . Leeb BF, Schweitzer H, Montag K, Smolen JS. Les Laboratoires Servier, 2006. Barenholdt, O., Kolthoff, N., and Nielsen, S. P. Effect of long-term treatment with strontium ranelate on bone strontium content. View abstract. Contact Dermatitis 2000;42(2):98-100. View abstract. View abstract. They won't do any studies but the END OF FRACTURES SAYS IT ALL! Results of a 2-year study. Osteoporos.Int. View abstract. I found that Strontium is eliminated by the kidneys and can build up in people with poor kidney function. Pelletier JP, Roubille C, Raynauld JP, et al. Go to the Bones, Joints & Muscles Support Group. Protos [Product Information]. Sr supplements are controversial and should be considered very carefully. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. Osteoporos.Int. View abstract. View abstract. View abstract. Nephrol.Dial.Transplant. 2008;83(5):308-314. View abstract. Osteoporosis treatment: Medications can help Osteoporosis treatment may involve medication along with lifestyle change. Collins, J. F. and Perkins, L. Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. View abstract. How can Sr be used? Zinc: Benefits, intake, sources, deficiency, and side effects View abstract. Ter.Arkh. View abstract. Why Strontium Is Not Advised for Bone Health Hahn, G. S. Strontium is a potent and selective inhibitor of sensory irritation. [1] PRAC recommends suspending use of Protelos/Osseor. 2014. Receive updates and information about Bone Health, Our Events, and Specialty Programs each month. If youre suffering from bone or prostate cancer, radioactive strontium therapyshould only be given by or under the direct supervision of a doctor with specialized training in nuclear medicine or radiation oncology. View abstract. BORON: Overview, Uses, Side Effects, Precautions, Interactions - WebMD 2013 Sep 4;93(5):520-6. doi: 10.2340/00015555-1564. Lets take a look at the possible health benefits of strontium. Clin Nucl Med 2004;29:81-5. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Strontium is a natural element. Its also used to create that alerting red color in emergency flares. Its also not for people who: National Osteoporosis Foundation Clinical Updates: "Over-the-Counter Products & Osteoporosis: Case Discussions. Strontium ranelate acts through dual mechanisms of inhibiting resorption by osteoclasts and maintaining or stimulating bone formation by osteoblasts. Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. Faith123 may", "Hello @bonelady -- welcome to Connect. View abstract. Strontium Ranelate returns to the UK as an osteoporosis drug treatment. 2019, As a service to our readers, American Bone Health provides access to our library of archived content. Maheu E, Mazieres B, Valat JP, et al. In the human body, approximately 99 percent of Sr is located in the bones. Given that strontium test results are tied to the strontium ion, citrate is your best option to reap its bone-building benefits. Acta Biomater. (21). Best Joint Supplements 2023: Top 3 Products Review & Compare J Rheumatol 2000;27:205-11. It has shown only a modest effect in preventing recurrent vertebral fractures. View abstract. View abstract. Gunawardana DH, Lichtenstein M, Better N, Rosenthal M. Results of strontium-89 therapy in patients with prostate cancer resistant to chemotherapy. A special form of strontium called strontium ranelate can increase bone formation and prevent bone loss when used in postmenopausal women with osteoporosis. Krachler, M., Domej, W., and Irgolic, K. J. Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial. Arthritis Rheum 1998;41:81-91. Incidence and mortality of venous thrombosis: a population-based study. However, I dont advocate using these supplements without first reviewing the precautions listed below and talking with your health care provider. Toxicological profile for strontium. One scientific review published in 2014 by a doctor with admitted ties to pharmaceutical makers concludes, The increased risk for cardiac events with strontium ranelate has been detected in randomized clinical trials but not in real-life observational studies. (9), Ultimately, the European Union now only endorses the use of strontium ranelate in severe cases of osteoporosis with high fracture risk. Strontium biokinetics in humans: influence of alginate on the uptake of ingested strontium. O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane Musculoskeletal Group. Chemical exchange between glass-ionomer restorations and residual carious dentine in permanent molars: an in vivo study. Good luck to all of you. Strontium absorption also has effects on the absorption ofcalcium, magnesium and phosphate ions. Am J Med. Rachitogenic activity of dietary strontium. (1) A radioactive form is even used as a form of cancer treatment for bone cancers andprostate cancer. Modawal, A., Ferrer, M., Choi, H. K., and Castle, J. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Although many people have never heard of it before, its a very interesting and somewhat controversial supplement. The naturally occurring form is made up of four stable isotopes: Sr-88 (82.6 percent), Sr-86 (9.9 percent), Sr-87 (7.0 percent), and Sr-84 (0.56 percent). Hello @bonelady. Gillam, D. G., Newman, H. N., Davies, E. H., and Bulman, J. S. Clinical efficacy of a low abrasive dentifrice for the relief of cervical dentinal hypersensitivity. Do not be misled by marketing materials that compare them to strontium ranelate. (23), In general, taking very high doses of a Sr supplement is typically not considered safe and taking too much could even damage bones, so be careful when taking strontium, as recommended by the ATSDR (Agency for Toxic Substances and Disease Registry). View abstract. It boils at 2,520 degrees F (1,382 degrees C) and melts at1,431 degrees F (777 degrees C). It's derived from rock calcium bound with citric acid (think citrus juices, especially lime and lemon). It is also shown to positively impact the body's usage of testosterone, estrogen, and vitamin D. https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869, https://connect.mayoclinic.org/discussion/reclast-infusion/, https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/. Since strontium is denser than calcium, it is difficult to assess actual bone improvement in a DXA scan. 2007;357:nihpa40967. 2017 Aug;55(8):93-94. 12-15-2007;57(8):1410-1418. Quintessence.Int. A common therapeutic dose you will often seen recommended for boosting bone health is 680 milligrams per day. FreshSplash/Getty Images. 2004;86-A(3):538-545. 2013 Feb;98(2):592-601. doi: 10.1210/jc.2012-3048. Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J. Y., Hodsman, A. Calcium and strontium metabolic studies in patients on CAPD. Canadian Advisory Board on Dentin Hypersensitivity. However, there has also been concern over strontium ranelates effects on heart health. Note that the numbers in parentheses (1, 2, etc.) What supplements help Osteopenia, Osteoporosis? - Mayo Clinic Connect Antacids are used to decrease stomach acid. View abstract. Many consumers are being lured by the advertised benefits of strontium for bone health. Sairanen S, Karkkainen M, Tahtela R, et al. You may not realize it, but its possible that you have used, or are currently using, a toothpaste the contains strontium. Dahl SG, Allain P, Marie PJ, et al. 2003. Calcif Tissue Int 2000;67:122-7. Arch.Intern.Med. "Hello @bonelady. View abstract. Some years later in 1808, it was was isolated in its metallic formusing electrolysisby Sir Humphry Davy at the Royal Institution in London. View abstract. Osteoporos Int. View abstract. Rizzoli R, Chapurlat RD, Laroche JM, et al. Bruyre O, Reginster JY, Bellamy N, et al. Apostolidis N, Paradellis T, Karydas A, et al. . Kidney Int 1999;56:1886-92. 5 Possible (and Controversial) Health Benefits, The Foods, Supplements & Oils to Increase Bone Healing, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More. The following doses have been studied in scientific research: Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox. Hernandez, F., Mohammed, C., Shannon, I., Volpe, A., and King, W. Clinical study evaluating the desensitizing effect and duration of two commercially available dentifrices. Blitzer, B. Some people say this supplement improves bone health, but its important to think about its benefits and risks before you decide to take it. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., Wang, O., and Mitlak, B. H. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. Available at: https://www.guildlink.com.au/gc/ws/servier/pi.cfm?product=sepproto. View abstract. 2003;14 Suppl 3:S56-S65. This article will be helpful to you if you experience joint discomfort, especially from rheumatoid arthritis and other joint health disorders. I am actively and urgently in the process of deciding which osteoporosis treatment I want to "pitch" to my doctors. View abstract. J.Clin.Periodontol. Strontium is a mineral found in seawater and soil. Towheed TE, Maxwell L, Anastassiades TP, et al. Ann.Rheum.Dis. Periodontics. Strontium citrate and strontium chloride are supplements and are not tested or regulated by the Food and Drug Administrations (FDA). Upset stomach and diarrhea are the most common side effects of magnesium oxide. JAMA 8-18-1999;282(7):637-645. Osteoporos.Int. Connect with thousands of patients and caregivers for support and answers. Lo, G. H., LaValley, M., McAlindon, T., and Felson, D. T. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. The disease often progresses without any symptoms or pain, and is not found until bones fracture. J.Bone Miner.Res. AlgaeCal Strontium Boost Reviews - CSUPERB I now take 680 mg strontium citrate without side effects and the fractures have stopped. View abstract. I will be contacting my urologist who I just began working with to let her know about Strontium. A. A., Christiansen, S. C., Romundstad, P., Cannegieter, S. C., Rosendaal, F. R., and Hammerstrom, J. Please note the date of the last review on all articles. 2005 - 2023 WebMD LLC. Center for drug evaluation and research. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects.